Cyclosporine: Indications, Side Effects, Warnings. Generic Name: cyclosporine (SYE- kloe- SPOR- in)Brand Name: Sandimmune. Cyclosporine should be used with adrenal corticosteroids (eg, hydrocortisone). It should not be used with other medicines that suppress the immune system. Suppressing the immune system may increase the risk of developing an infection or a certain type of cancer (lymphoma). Cyclosporine cannot be switched with other forms of cyclosporine (eg, Neoral) without your doctor's approval. If you are taking cyclosporine for a long period of time, lab tests should be performed to monitor your progress or to check for side effects. This is especially important for liver transplant patients. Cyclosporine is used for: Preventing the rejection of organ transplants (kidney, liver, and heart). It is used in combination with adrenal corticosteroids. It may also be used to treat chronic rejection in patients previously treated with other immunosuppressive agents. It may also be used for other conditions as determined by your doctor. Cyclosporine is an immunosuppressant. It works by suppressing the immune system. Find patient medical information for cyclosporine oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
This prevents the body from rejecting transplanted organs. Do NOT use cyclosporine if: you are allergic to any ingredient in cyclosporine or to Cremophor ELyou are taking aliskiren, amiloride, bosentan, dabigatran, orlistat, spironolactone, or triamtereneyou are taking another medicine to suppress the immune system (eg, azathioprine, sirolimus)you are having radiation therapy, including psoralen ultraviolet A (PUVA) or ultraviolet B (UVB) therapy, for psoriasis. Contact your doctor or health care provider right away if any of these apply to you. Before using cyclosporine: Some medical conditions may interact with cyclosporine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you: if you are pregnant, planning to become pregnant, or are breast- feedingif you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplementif you have allergies to medicines, foods, or other substancesif you have liver, kidney, brain, or nerve problems; gout or high blood uric acid levels; low blood magnesium or cholesterol levels; high blood pressure; cancer; an infection; a weakened immune system; or problems absorbing food or medicineif you have high blood potassium levels or your diet contains a lot of potassiumif you have a history of seizuresif you are having phototherapy for psoriasis or are having radiation treatmentif you have recently had or will be having a vaccineif you are taking medicines that may harm the kidney (eg, aminoglycoside antibiotics . Flaxseed Oil Benefits, Side Effects, Reviews and Facts (Linseed Oil).Ask your doctor if you are unsure if any of your medicines might harm the kidney or liver. Some MEDICINES MAY INTERACT with cyclosporine. Tell your health care provider if you are taking any other medicines, especially any of the following: Many prescription and nonprescription medicines (eg, used for aches and pains, allergic reactions, arthritis, asthma, birth control, blood thinning, cancer, diabetes, endometriosis, fibrocystic breast disease, gout, heartburn or reflux, hepatitis C, high blood pressure, high blood prolactin levels, HIV, infection, immune system suppression, inflammation, high cholesterol, irregular heartbeat or other heart problems, mental or mood problems, Parkinson disease, psoriasis, pulmonary arterial hypertension . John's wort) because they may interact with cyclosporine. Ask your doctor or pharmacist if you are unsure if any of your medicines might interact with cyclosporine. This may not be a complete list of all interactions that may occur. Ask your health care provider if cyclosporine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. How to use cyclosporine: Use cyclosporine as directed by your doctor. Check the label on the medicine for exact dosing instructions. Cyclosporine is given as an injection at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions. Do not eat grapefruit or drink grapefruit juice while you use cyclosporine. If you miss a dose of cyclosporine, call your doctor to find out what to do. Ask your health care provider any questions you may have about how to use cyclosporine. Important safety information: Tell your doctor or dentist that you take cyclosporine before you receive any medical or dental care, emergency care, or surgery. Do not switch to another doseform or change brands of cyclosporine without talking to your doctor. Products made by other companies may not work as well for you. Cyclosporine may increase your risk of skin cancer. Avoid the sun, sunlamps, or tanning booths until you know how you react to cyclosporine. Use a sunscreen or wear protective clothing if you must be outside for more than a short time. It may also increase your risk of developing other forms of cancer (eg, lymphoma). Discuss any questions or concerns with your doctor. Cyclosporine may lower the ability of your body to fight infection. This may increase the risk of serious and sometimes fatal infections. Avoid contact with people who have colds or infections. Tell your doctor right away if you notice signs of infection like fever, sore throat, rash, or chills. Some patients treated with cyclosporine have developed severe and sometimes fatal infections, such as progressive multifocal leukoencephalopathy (PML) or severe kidney problems associated with BK virus infection. In kidney transplant patients, BK virus infection may cause loss of the transplanted kidney. Tell your doctor right away if you notice symptoms of PML (eg, confusion or disorientation; you do not care about things that you usually care about; changes in thinking, strength, or vision; one- sided weakness; trouble walking or talking; loss of balance or coordination) or kidney problems (eg, change in the amount of urine produced, difficult or painful urination, blood in the urine). Do not receive a live vaccine (eg, measles, mumps) while you are taking cyclosporine. Talk with your doctor before you receive any vaccine. Cyclosporine may reduce the number of clot- forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools. Check with your doctor before you use a salt substitute or a product that has potassium in it. Diabetes patients - Cyclosporine may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. Have your blood pressure checked as you have been told by your doctor. Lab tests may be performed while you use cyclosporine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Use cyclosporine with caution in the ELDERLY; they may be more sensitive to its effects. PREGNANCY and BREAST- FEEDING: Cyclosporine may cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using cyclosporine while you are pregnant. Cyclosporine is found in breast milk. Do not breast- feed while taking cyclosporine. Possible side effects of cyclosporine: All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome: Acne; dizziness; headache; increased hair growth; mild diarrhea; nausea; runny nose; sleeplessness; stomach discomfort; vomiting. Seek medical attention right away if any of these SEVERE side effects occur: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; burning, numbness, or tingling; change in the appearance of a mole; chest, jaw, or arm pain; confusion; decreased coordination; fast or irregular heartbeat; gum disease or overgrowth; mental or mood changes (eg, depression); mouth sores or swelling; muscle aches, cramps, pain, or weakness; ringing in the ears or hearing loss; seizures; severe or persistent diarrhea; severe or persistent headache or dizziness; shortness of breath; stomach pain; sudden unusual sweating; symptoms of infection (eg, chills, fever, increased or painful urination, sore throat, severe or persistent cough, warm or painful skin); symptoms of kidney problems (eg, change in the amount of urine produced, difficult or painful urination, blood in the urine); symptoms of liver problems (eg, dark urine; pale stools; severe or persistent nausea, vomiting, or loss of appetite); tremor; unusual bleeding or bruising; unusual lumps; unusual swelling; unusual thickening or growth on the skin; unusual tiredness or weakness; vision changes (eg, blindness); vomit that looks like coffee grounds; wheezing; yellowing of the skin or eyes. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA. If OVERDOSE is suspected: Contact 1- 8. American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Proper storage of cyclosporine: Cyclosporine is handled and stored by a health care provider. You will not store it at home. Keep all medicines out of the reach of children and away from pets. General information: If you have any questions about cyclosporine, please talk with your doctor, pharmacist, or other health care provider. Cyclosporine is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor.
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